How do you most accurately differentiate bvFTD from EOAD by clinical criteria?

Research article, published in Journal of Alzheimers Disease, doi: 10.3233/JAD-215667.
Authors: Somayeh Meysami, Cyrus A. Raji, Mario F. Mendez

A study published earlier this month in the Journal of Alzheimer’s investigated if volumetric quantification of brain MR imaging can identify persons with behavioral variant frontotemporal dementia (bvFTD) from early-onset Alzheimer’s disease (EOAD).

Both disorders are the most common causes of neurodegenerative dementia among persons in their 50s and early 60s and have a high rate of misdiagnosis when based on clinical grounds. In the study, two comparable groups with regards to age and sex were tested, one group with bvFTD and the other with EOAD.

The researchers used two volumetric software programs – volBrain and Neuroreader®. To reveal some of the results, Neuroreader® showed 99.3% correct classification in the ROC.

Read an elaborated summary here.